Multiple personalities of the RNA polymerase active centre
نویسندگان
چکیده
منابع مشابه
Controlled interplay between trigger loop and Gre factor in the RNA polymerase active centre
The highly processive transcription by multi-subunit RNA polymerases (RNAP) can be interrupted by misincorporation or backtracking events that may stall transcription or lead to erroneous transcripts. Backtracked/misincorporated complexes can be resolved via hydrolysis of the transcript. Here, we show that, in response to misincorporation and/or backtracking, the catalytic domain of RNAP active...
متن کاملThe multiple personalities of Alix
Introduction Proteins that can regulate seemingly disparate mechanisms do so by engaging in multiple distinct protein interaction networks. Such multifunctional activities are characteristic of a protein in mammalian cells known as 'Alix' or 'AIP1'. Both names derive from its original discovery as an interaction partner of ALG-2, a Ca 2+-binding protein implicated in apoptotic signaling (Missot...
متن کاملThe multiple personalities of Alix.
Alix is a cytosolic protein in mammalian cells that was originally identified on the basis of its association with pro-apoptotic signaling. More recent evidence has established that Alix has a hand in regulating other cellular mechanisms, including endocytic membrane trafficking and cell adhesion. Although Alix appears to participate directly in these various activities, the role it plays in ea...
متن کاملthe investigation of the relationship between type a and type b personalities and quality of translation
چکیده ندارد.
Norovirus proteinase-polymerase and polymerase are both active forms of RNA-dependent RNA polymerase.
In vitro mapping studies of the MD145 norovirus (Caliciviridae) ORF1 polyprotein identified two stable cleavage products containing the viral RNA-dependent RNA polymerase (RdRp) domains: ProPol (a precursor comprised of both the proteinase and polymerase) and Pol (the mature polymerase). The goal of this study was to identify the active form (or forms) of the norovirus polymerase. The recombina...
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ژورنال
عنوان ژورنال: Microbiology
سال: 2014
ISSN: 1350-0872,1465-2080
DOI: 10.1099/mic.0.079020-0